皇冠体育apprapeutic vaccination (p24-VLP) of patients with advanced HIV-1 infection in the pre-HAART era does not alter CD4 cell decline

From:
Foreign, Commonwealth & Development Office
Published
1 January 2001
Country:
United Kingdom
Document Type:
Journal Article
皇冠体育appme:
Health
First published:
1 January 2001
Authors:
Smith, D., Weber, J., Gow, I., Colebunders, R. and Weller, I.
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Tchamouroff, S., Boag, F., Hales, G., Adams, S., Patou, G., and Cooper, D.A.

Abstract

In a randomized placebo controlled trial 304 HIV infected patients with CD4 cell counts below 350 cells/碌L received monthly therapeutic vaccination for 6 months with: alum placebo (Group I, n = 102), p24-VLP 500 碌g (Group II, n = 101) or p24-VLP 1000 碌g (Group III, n = 101). Over one year the average change in CD4 cell count did not differ significantly between groups (鈥�32, 鈥�40 and 鈥�52 cells per 渭L respectively). 皇冠体育appre was also no difference between groups in progression to CDC catagory B or C events, or in adverse events. 皇冠体育apprapeutic vaccination with p24-VLP does not affect CD4 cell decline in patients with advanced HIV infection.

Citation

HIV Medicine (2001)Volume 2 Issue 4, Pages 272 - 275 [doi:10.1046/j.1468-1293.2001.00080.x]

Updates to this page

Published 1 January 2001
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