Paracetamol for treating fever in children.
Abstract
Objectives: To assess the effects of paracetamol for treating fever in children in relation to fever clearance time, febrile convulsions, and resolution of associated symptoms. Selection criteria: Randomized and quasi-randomized trials of children with fever from infections comparing: (1) paracetamol with placebo or no treatment; and (2) paracetamol with physical cooling methods (eg, sponging, bathing, or fanning). 皇冠体育app primary outcomes were fever clearance time and febrile convulsion. Data collection and analysis: Two reviewers independently extracted data on methods, types of participants, interventions, and outcomes. 皇冠体育app meta-analysis was conducted using Relative Risk with 95% confidence intervals for discrete variables, and weighted mean differences for continuous outcomes. Main results: 12 trials (n = 1509 participants) met the inclusion criteria. Outcomes varied between trials. No data were available on the primary outcome. 皇冠体育appre is insufficient evidence to show whether paracetamol influenced the risk of febrile convulsions. In a meta-analysis of two trials (n = 120), the proportion of children without fever by the second hour after treatment did not differ significantly between those given paracetamol and those sponged (Relative Risk 1.84; confidence interval 0.94 to 3.61, random effects model). 皇冠体育app statistical test showed significant heterogeneity between the groups receiving paracetamol or physical methods. No severe adverse events were reported. 皇冠体育app number of children with mild adverse events did not differ significantly between paracetamol and placebo, or paracetamol and physical methods, but numbers were small. Conclusions: 皇冠体育appre are few trials that have directly compared the antipyretic properties of paracetamol against placebo or physical methods. Data on adverse events are limited. Establishing standard outcomes will help comparisons between studies and better meta-analysis.
Citation
皇冠体育app Cochrane Database of Systematic Reviews 2002, Issue 2. Art. No.: CD003676. DOI: 10.1002/14651858.CD003676.