皇冠体育app

皇冠体育app British Council and the British Embassy, Israel, have given the go-ahead to seven, new, three-year bilateral scientific projects in the field of research on ageing. 皇冠体育app work will be carried out by top institutions in the UK and Israel.

皇冠体育app projects will be awarded nearly 拢2.8 million in total from , a 拢10 million programme to support cutting edge UK-Israeli research.

BIRAX Ageing will look at the effects of ageing on human health, and the use of precision medicine and big data in ageing research. It will bring together scientists from the Hebrew University, Hadassah Medical Centre, Tel Aviv University, Tel Aviv Sourasky Medical Centre, University of Oxford, University of Cambridge, King鈥檚 College London, and Queen鈥檚 University Belfast.

皇冠体育app projects will focus on various aspects of ageing and how it affects diabetes, vascular disease, neuro-degenerative disease such as Multiple Sclerosis, brain imaging, as well as the use of technology for macular disease research.

British Ambassador to Israel, Mr. Neil Wigan said:

I am excited that seven new projects have been selected for the first call of BIRAX Ageing, the latest phase of our flagship science research programme. 皇冠体育appse cutting-edge research collaborations not only position the UK and Israel at the forefront of ageing research world-wide, but also reaffirm the close connection between British and Israeli academic communities and establishments. Through these meaningful and sustainable collaborations, we can together tackle universal ongoing challenges.

BIRAX Ageing research looks at the global challenges of ageing, bringing together world-class and complementary scientific capabilities to promote healthy ageing. It aims to establish and grow a substantial new academic community and support ground-breaking collaborative research in the field of ageing, funding both research mobility and joint research projects over the next five years. This crucial research will be generously supported by the Pears Foundation, 皇冠体育app Israel Ministry of Science and Technology, 皇冠体育app Parasol Foundation Trust, Charles Wolfson Charitable Trust, 皇冠体育app Rosetrees Trust, Diabetes UK, 皇冠体育app British Heart Foundation, and MS Society.

Sir Trevor Pears, Executive Chair of the Pears Foundation, added:

Since its establishment in 2011, the BIRAX Initiative has earned its excellent reputation for successfully nurturing UK鈥揑srael scientific exchange for the advancement of knowledge. We are proud to have been the founding partner of this important initiative, which will have an enduring impact and legacy, and are delighted to be part of a family of committed partners.

BIRAX was initiated 8 years ago by the British Council, British Embassy in Israel and the UK Science and Innovation Network in collaboration with the Pears Foundation as a founding partner. So far, BIRAX has funded 19 research projects tackling some of the world鈥檚 most challenging health conditions and diseases by employing pioneering regenerative medicine and stem cell therapies and using the most advanced and cutting-edge technologies. 皇冠体育app ground-breaking science has been made possible through the generous support of a broad family of partners and supporters including the Israel Ministry of Science and Technology, the British Heart Foundation, JDRF, MS Society, Parkinson鈥檚 UK, Alzheimer鈥檚 Society, the Medical Research Council, 皇冠体育app Parasol Foundation Trust, 皇冠体育app Rosetrees Trust, Weizmann UK, Clore Foundation Israel, Charles Wolfson Charitable Trust, 皇冠体育app Wolfson Foundation, 皇冠体育app Maurice and Vivienne Wohl Philanthropic Foundation, 皇冠体育app Kahn Foundation, UJIA, Celia and Edward Atkin, 皇冠体育app Sheila and Denis Cohen Charitable Trust, 皇冠体育app Barbara and Stanley Fink Foundation, and 皇冠体育app Glycobiology Institute of Oxford University.

皇冠体育app funded projects are:

• Age-related bone fragility in type 1 diabetes 鈥� the role of bone cell senescence

Principal Investigators: Professor Lynne Cox, University of Oxford Professor Rivka Dresner Pollak, Hadassah Medical Center

皇冠体育app overall aim of this research is to understand bone fragility in ageing patients with type 1 diabetes who are currently at high risk of bone fracture and premature death, and to develop new treatments.

• Microstructural MRI of the ageing brain

Principal Investigators: Professor Heidi Johansen-Berg, University of Oxford Professor Yaniv Assaf, Tel Aviv University

皇冠体育app project will explore neurodegenerative processes in age related disease such as dementia by understanding the processes behind 鈥渉ealthy鈥� brain ageing. Owing to dramatic developments in brain imaging methods for providing quantitative measures of brain microstructure, in particular, in Prof Assaf鈥檚 lab in Tel Aviv, these methods could be particularly powerful ways to detect subtle changes in brain structure occurring with ageing, providing early indicators of age-related neurodegeneration. No database of microstructural imaging yet exists.

This project aims to create the first database of microstructural imaging and to initiate a brain database in Israel.

• How does ageing-associated niche stiffening disrupt nucleus mechanotransduction signaling and suppresses the regenerative capacity of adult CNS progenitor cells?

Principal Investigators: Professor Robin Franklin, University of Cambridge Dr Amnon Buxboim, Hebrew University of Jerusalem

This project seeks to find answers that will provide clues as to how the effects of age might be reversed therapeutically. It will examine how the brain is able to induce harmful in central nerve system stem cells, and how are the physical signals of the brain transmitted to a central nerve system stem cell to change its function.

• Vascular Ageing, Rejuvenation and Healthspan Extension

Principal Investigators: Professor Manuel Mayr, King鈥檚 College London Professor Eli Keshet, Hebrew University of Jerusalem

This project proposes a novel anti-ageing approach to combat age-associated deterioration of vascular function. 皇冠体育app knowledge gained in the project will be leveraged for the development of new anti-aging treatments.

• Cellular senescence, aging and diabetes

Principal Investigators: Professor Masashi Narita, University of Cambridge Professor Ittai Ben-Porath, Hebrew University of Jerusalem

This project addresses in depth the roles of beta-cell senescence in aging and diabetes. 皇冠体育app researchers aim to uncover whether beta-cell senescence contributes to, or, alternatively acts to counteract diabetes.

• Algorithms for diagnosis and management of age-related macular degeneration

Principal Investigators: Professor Tunde Peto, Queen鈥檚 University Belfast Professor Anat Loewenstein, Tel Aviv University

This project aims to investigate the performance of new automated software algorithms to monitor AMD and detect progression, towards implementation in routine patient鈥檚 management; and to investigate the potential for machine learning to identify factors and biomarkers associated with long-term AMD treatment response.